MAP2K3 and plasma cell myeloma: 2001). Moreover, we find two driver/hub genes, FLT4 and MAP2K3 with degrees 9 and 8, both of which play important roles in multiple myeloma. FLT4, also known as VEGFR3, is responsible for angiogenesis for multiple myeloma (Kumar et al. 2003) and MAP2K3 contributes to the development of multiple myeloma through MAPK cascades (Leow et al. 2013).