Based on the serum albumin level at the termination of CRRT, the initial hypoalbuminemia group was further categorized into persistently low (serum albumin < 3.0 g/dL at CRRT termination) and increasing (serum albumin ≥ 3.0 g/dL at CRRT termination) groups; the initial normoalbuminemia group was further categorized into decreasing (serum albumin < 3.0 g/dL at CRRT termination) and persistently high (serum albumin ≥ 3.0 g/dL at CRRT termination) groups. The gene discussed is ALB; the disease is Hypoalbuminemia.