ROS1 and osteoporosis: For example, puerarin can improve cyanin-induced chronic pancreatitis by inhibiting MAPK signaling, as concluded by Zeng et al. [38] As discovered by XIAO, et al., through inhibiting TRAF6/ ros-dependent MAPK/NF-κB signaling pathway, puerarin can inhibit the formation of osteoclasts and reduce osteocast-associated bone mass loss in mice with oophorectomy (OVX) -induced osteoporosis [39].