IL18 and acute respiratory distress syndrome: In this secondary analysis of the HARP-2 clinical trial [9], we confirmed that baseline plasma IL-18 (≥ 800 pg/ml) is associated with mortality in a broad population of patients with ARDS, and present the novel finding that simvastatin may be associated with reduced mortality in patients with ARDS who have high baseline plasma IL-18 (≥ 800 pg/ml).