IL6 and idiopathic pulmonary fibrosis: IL-6 binds to sIL-6R and activates the membrane-bound glycoprotein 130 (gp130), then actives Jak/signal transducer and activator of transcription (STAT) signaling pathway [53], which is implicated in a variety of inflammatory processes, including IPF [54, 55] and asthma [56].