CD34 and coronary artery disorder: Previous data indicated that RA altered the gene expression profile of CD34+ cells in coronary artery disease patients in a manner related to activation of differentiation via a retinoic acid-induced differentiation program, suggesting that circulating CD34+ cells in coronary artery disease patients are programmed by RA, leading to a reduced capacity to migrate to ischemic tissues, which in turn may be a reason for the reduced angiogenesis [31].