TGF-β1 suppresses the growth of HCC by inducing the upregulation of LATS1 and nucleocytoplasmic translocation and degradation of YAP1 [25], while positive crosstalk between the TGF-β–SMAD and YAP1/TAZ pathways has also been observed. Here, TGFB1 is linked to hepatocellular carcinoma.