The strongest enrichments for MS GWAS were observed in OCRs from CD4 T cells (enrichment p-value = 1.47×10−18), CD8 T cells (p-value = 4.00×10−18), and B cells (p-value = 3.27×10−15); reflecting their known and emerging roles in MS pathogenesis and as targets of treatment [1, 3, 23]. This evidence concerns the gene CD8A and myeloid sarcoma.