In a mouse model of GVHD, co-incubation of MSC-derived EVs by THP-1 cells induced the creation of CD4 + CD25 + T cells or CD4 + CD25 + Foxp3 + Tregs from CD4 + T cells activated by allogeneic APC-enriched CD11C + cells. The gene discussed is CD4; the disease is graft versus host disease.