Second, to further investigate the cytolytic activity of NK cells, we evaluated the production of the classic degranulation marker CD107a (lysosome-associated membrane protein-1, LAMP-1), as well as that of perforin and granzyme B (GzmB) which are potential cytolytic biomarkers of NK cells and T lymphocytes [45–47] by flow cytometry after coculturing NK cells with CML-RAE-1γ-Dex or various controls. The gene discussed is GZMB; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.