Moreover, based on our observations that CML-RAE-1γ-Dex possessed higher immunostimulatory activity than CML-specific Dex without RAE-1γ modification, we next wanted to investigate whether the NKG2D/NKG2D-L (RAE-1γ) pathway is a crucial determinant in NK/T-cell activation induced by modified Dex. This evidence concerns the gene KLRK1 and chronic myelogenous leukemia, BCR-ABL1 positive.