TLR4 and retinal disorder: Subgroup analysis by race and different type of microvascular complications, we found that TLR4 gene Asp299Gly polymorphism was associated with increased risk of microvascular complications in the Caucasian population (dominant model OR = 1.69, 95% CI 1.22–2.35, P = 0.002; allelic model OR = 1.56, 95% CI 1.10–2.21, P = 0.01) and increased the risk of retinopathy in patients with T2DM(dominant model OR = 1.81, 95% CI 1.04–3.14, P = 0.03; allelic model OR = 1.77, 95% CI 1.05–2.98, P = 0.03).