TLR4 gene Asp299Gly polymorphism increased the risk of microvascular complications in T2DM (dominant model OR = 1.52, 95% CI 1.10–2.09, p = 0.01; allelic model OR = 1.42, 95% CI 1.02–1.96, p = 0.04). The gene discussed is TLR4; the disease is type 2 diabetes mellitus.