However, after inhibiting miR-18a-5 in EVs, miR-18a-5p was lowered, levels of NACC1 mRNA, p-AKT and p-mTOR were elevated, the ability of EVs to inhibit tumor growth was obviously weakened, the number of lung metastatic nodules was raised (all P < 0.01) (Fig. 8E–K). Here, AKT1 is linked to neoplasm.