TP53 and colorectal carcinoma: We downregulated the expression of TRIM2 in cells treated with EPI for five days, which suppressed the EPI-induced regulation of p53 (Fig. 7A–C) and EMT transformation (Fig. 7A–C) as well as CSC generation (Fig. 7A–F), migration (Fig. 7G, H and Additional file 6: Fig. S6A, B), and proliferation (Fig. 7I, J and Additional file 6: Fig. S6C, D) in CRC.