TP53 and colorectal carcinoma: We next investigated the function of TRIM2 in CRC and observed that TRIM2 promoted p53 downregulation (Fig. 5D and Additional file 4: Figure S4C-4D) and EMT transformation (Fig. 5D and Additional file 4: S4C, D) as well as CSC generation (Fig. 5D, G and Additional file 4: Figure S4C, D), migration (Fig. 5H, Iand Additional file 4: Figure S4E, F) and proliferation (Fig. 5J, K and Additional file 4: Figure S4G, H) in CRC.