TNF and legionellosis: It shows that Simiao Powder achieves its therapeutic effect for gout treatment through multiple pathways, mainly including AGE-RAGE signaling pathway in diabetic complications, Fluid shear stress and atherosclerosis, HIF-1 signaling pathway, NF-kappa B signaling pathway, TNF signaling pathway, EGFR tyrosine kinase inhibitor resistance, Cytosolic DNA-sensing pathway, Th17 cell differentiation Legionellosis, NOD-like receptor signaling pathway、PI3K-Akt signaling pathway.