Nevertheless, locally-advanced demonstrated better post RT mean Hb level (12.85 g/dL vs 11.77 g/dL; p = 0.01) and also better anemia improvement (68.6% vs 21.9%; p  < 0.001) in RT-alone vs RT plus cetuximab; which was not demonstrated in those of early disease (12.94 vs 12.61 g/dL; p = 0.54, and 15.7% vs 9.5%; p = 0.71) for RT-alone vs RT plus cetuximab respectively. This evidence concerns the gene GSTM1 and anemia.