The downregulated pathways of HCC-186 were majorly enriched by the genes such as IKBKE, PDGFB, IL12A, IL1A, IRAK1, ITGB2, MYC, CALML4, ADCY7, TLR4, CALML5 and IL1B. The gene discussed is ADCY7; the disease is hepatocellular carcinoma.