The phosphatidylinositol-3 kinase (PI3K)-Akt signaling pathway (e.g., G2/G1, G4/G3, G5/G4, G6/G5, and G6/G1), Hippo signaling pathway (e.g., G2/G1), peroxisome proliferator-activated receptor (PPAR) signaling pathway (e.g., G3/G2 and G4/G3), mitogen-activated protein kinase (MAPK) signaling pathway (e.g., G5/G4), and ECM–receptor interaction pathways (e.g., G2/G1, G5/G4, G6/G5, and G6/G1), which have been reported to play indispensable roles during HF development, were enriched. The gene discussed is WNK2; the disease is hydrops fetalis.