We documented HRQoL measured using \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\hbox {PedQL}^{TM}$$\end{document}PedQLTM and clinically relevant health outcomes in children diagnosed with syndromic autism (PMD, SYNGAP1-ID and RTT) along with the environment they experienced during the early phases of the COVID-19 pandemic. The gene discussed is SYNGAP1; the disease is autism.