However, Bifidobacterium longum EPS significantly suppressed LPS-induced anxiety-/depression-like behaviors, hippocampal NF-κB+/Iba1+ cell population, and blood LPS level and induced LPS-suppressed hippocampal BDNF+/NeuN+ cell population and claudin-5 expression. The gene discussed is NFKB1; the disease is depressive symptom measurement.