IL10 and neoplasm: They are poised to rapidly produce significant amounts of Th1- (IFNγ), Th2 (IL-4 and IL-10), Th10 (IL-10), Th17 (IL-17), or T-Follicular Helper (IL-21)-type cytokines upon activation, and have been implicated not only in anti-microbial and anti-tumor immunity, but also in the pathogenesis and regulation of a variety of inflammatory disorders, such as autoimmune diseases2–5.