GAD2 and medulloblastoma: A Gad2 promoter region containing these 3 potential MAREs was then cloned into the pGL3 Luciferase reporter vector (Gad2-Luc) and a medulloblastoma cell line was transfected with either control pGL3 (containing a minimal promoter without MAREs) or the Gad2-Luc vectors in the presence of increasing concentrations of plasmids encoding WT or Mafa-4A protein.