In these or other scenarios, as TGFβ is an essential regulator of cell proliferation, survival, differentiation, and plays a critical role in cancer and neurodegenerative disorders76, understanding how the phase separation of its coactivator JMJD3 impacts its regulatory processes could undoubtedly contribute to understanding the crosstalk between diseases and development, and potentially provide new therapeutic targets. The gene discussed is KDM6B; the disease is cancer.