PAX8 and endometrial cancer: To further explore the function of DDX5 and PAX8 on endometrial cancer cells, knockdown of PAX8 expression decreased the proliferation of both HEC-1B and Ishikawa cells relative to that of control cells, and reconstitution of c-MYC restored the proliferation of these cells (Fig. 6A–C, Supplementary Fig. 5), which also verifies that c-MYC is a downstream gene of PAX8.