We searched PubMed records published from Jan 1, 2009, to March 3, 2022, to identify publications directly relevant to the FAKTION clinical setting using the search terms “AKT” or “PI3K” or “mTOR” or “mTORC1” and “oestrogen receptor” and “breast cancer” and “metastatic” and “inhibitor” or “inhibition”. Here, AKT1 is linked to breast cancer.