These genes included nephronectin (Npnt) and periostin (Postn), upregulated in the outer bulge of the hair follicle (HF) (Fujiwara et al., 2011; Watt and Fujiwara, 2011), as well as the distinct laminin (LN) isoforms in the interfollicular epidermis (IFE) and upper HF (Morgner et al., 2015), which validated our approach. The gene discussed is MLPH; the disease is hydrops fetalis.