IFNG and secondary hemophagocytic lymphohistiocytosis: Prencipe et al. described a hepatic upregulation in transcription of genes involved in the IFN-γ pathway in children suffering from secondary hemophagocytic lymphohistiocytosis (HLH) with hepatitis, supporting the hypothesis that hepatocyte IFN-γ response could contribute to liver injury in HLH [3].