Importantly, human GWAS databases (GWASATLAS; https://atlas.ctglab.nl) demonstrate that FAM114A1 has a genetic SNP mutation related to hypertension phenotype in human CAD (ranked as 89 of 19,057 genes; P = 3.64 × 10–9) (Supplemental Figure 1A) (26). This evidence concerns the gene FAM114A1 and hypertensive disorder.