By contrast, there were no significant differences in the density of either CD68+ macrophages (Supplemental Figure 8A) or FOXP3+ Tregs (Supplemental Figure 8B) between C1D1 and C2D8 specimens or between the tumor nest and stromal area of tissue sections from patients with a durable CBR and nonresponders, respectively. The gene discussed is FOXP3; the disease is neoplasm.