KLRK1 and Friedreich ataxia: These data, together with in vitro as well as in vivo proof-of-principle experiments showing improved hematopoietic effects associated with the blockage of NKG2D–NKG2D-L interactions, demonstrate the relevance of cells of the innate immune system in the impaired growth of FA HSPCs and strongly implicate NKG2D–NKG2D-L interactions in the BMF characteristic of patients with FA.