As CHEK-1 inhibition significantly reduced NKG2D-L levels in FA HSPCs, we can speculate that the low levels of CHEK-1 present in these patients with attenuated FA may prevent the overexpression of NKG2D-Ls, limiting the recognition of these primitive hematopoietic cells by immune cells. This evidence concerns the gene CHEK1 and Friedreich ataxia.