Additionally, IDH wild-type diffuse astrocytic tumors in adults without the histological features of glioblastoma, but with one or more of three genetic parameters (telomerase reverse transcriptase gene [TERT] promoter mutation, epidermal growth factor receptor [EGFR] gene amplification, or combined gain of entire chromosome 7 and loss of entire chromosome 10 [+ 7/ − 10]) are now also classified as glioblastoma. The gene discussed is IDH1; the disease is glioblastoma.