TCF12 and colorectal carcinoma: Similarly, the GAS5 gene promoter rs55829688 variant was implicated in changing the gene expression via influencing the binding affinity of the transcriptional factor YY1 to the promoter region [39], and the prostate cancer-associated transcript 1 (PCAT1) rs2632159 may influence CRC risk by altering EBF, LUN-1, and TCF12 binding, thereby up-regulating PCAT1 expression and hence potentiate its carcinogenic role [40].