The oncogenic lncRNA PUNISHER, also known as “AGAP2-AS1 (ADP-ribosylation factor [Arf], GTPase-activated protein [GAP], isoform 2-antisense RNA 1)”, was recently reported to augment cell viability and mobility and confers gemcitabine resistance by inhibiting microRNA-497 in colorectal cancer (CRC) [10]. Here, AGAP2-AS1 is linked to colorectal carcinoma.