Interestingly, the obtained results showed that the PUNISHER rs12318065 A variant could influence binding with the transcriptional factors: POL2, STAT1, and ZNF263, which are linked to carcinogenesis [42–46], also it could alter regulatory motifs, including mrg1, HOXa9_1, and Sin3Ak-20_disc6 some of which have been confirmed to be associated with colon cancer carcinogenesis and metastasis [47]. Here, ZNF263 is linked to malignant colon neoplasm.