Bellutti et al. (2018) proposed that Cdk6 antagonizes p53-mediated stress responses arising in bone marrow cells upon oncogenic stress, and in the absence of Cdk6, the pro-apoptotic functions of p53 prevail. In a Parkinson’s disease mouse model with conditional loss of Fbxo7 in dopaminergic neurons, a p53 pro-apoptotic signature was detected (Stott et al., 2019). Here, CDK6 is linked to Parkinson disease.