This includes a pro-survival activity of cyclin D3/Cdk6 activity attributed to its phosphorylation and inhibition of glycolytic enzymes, phosphofructokinase (PFKP) and PKM2, in T acute lymphoblastic leukemia (T-ALL) cells and other tumors with high expression of Cdk6 (Wang et al., 2017). The gene discussed is PKM; the disease is acute lymphoblastic leukemia.