Consequently, in light of studies showing Cdk6 regulation of glycolytic enzymes is essential for the survival of T-ALL cells (Wang et al., 2017), we reasoned that Fbxo7 should be essential for viability in hematological malignancies, since Cdk6 is the major kinase expressed in these cell lineages. Here, FBXO7 is linked to acute lymphoblastic leukemia.