Besides blood coagulation, TMEM16F-mediated PS exposure has been increasingly reported to be important in cell-cell fusion and viral-cell fusion events including placental trophoblast syncytialization (Zhang et al., 2020), SARS-CoV2-mediated syncytialization (Braga et al., 2021) and HIV infection (Zaitseva et al., 2017). Here, ANO6 is linked to HIV infectious disease.