Consistent with its important role in blood coagulation, TMEM16F deficiency leads to defective thrombin generation and prolonged bleeding in Scott syndrome patients (Suzuki et al., 2010; Boisseau et al., 2018; Castoldi et al., 2011) and in TMEM16F knockout (KO) mice (Yang et al., 2012). Here, ANO6 is linked to Scott syndrome.