As a polymodal temperature, chemical and osmotic sensors in vertebrates, TRPV4 Ca2+ permeable channel is widely expressed and has been reported to be important for vascular function, joint biology and disease, nociception, itch, central nervous system regulation of systemic tonicity, neuroprotection, skin barrier, immune and neurosensory function, lung fibrosis, and skeletal integrity (Rosenbaum et al., 2020). The gene discussed is TRPV4; the disease is pulmonary fibrosis.