PIGW and Ito hypomelanosis: Although the precise mechanism by which FMGX synergistically (or additively) enhances the effect of L-AMB to treat experimental IPA, IM, and IF is yet to be determined, it is possible that inhibition of Gwt1, which results in the failure of GPI-anchored proteins to correctly localize to the outer surface structure, results in enhanced uptake of L-AMB by the microbial cell.