(A–B) Representative dot plots of granzyme B (GzB) and T-bet staining on gated CD4+ T splenocytes (left panels) and mean frequencies of T-bet+, IFN-γ+ and GzB+ CD4+ T cells and absolute numbers of GzB+CD4+ T cells (on the right) from (A) wild-type (B6) and Il12p40-/- mice on day 14 post-infection (pi) and (B) wild-type (WT) and Ifng-/- mice on day 11 pi. The gene discussed is CD4; the disease is infection.