Although etiology is commonly believed to be multifactorial, more than 90% of synovial sarcomas have a characteristic t(X,18) translocation (p11.2;q11.2), that causes the fusion of the SS18 gene on chromosome 18 with one of three closely related genes (SSX1, SSX2, and SSX4) on the X chromosome, resulting in an aberrant SSX transcription.3, 4, 5, 6. The gene discussed is SS18; the disease is synovial sarcoma.