As shown in Table 2, univariable logistic regression analysis revealed that the risk of esophageal cancer was significantly associated with the C allele of ADH1B rs1229984, and both the TC and CC genotypes contributed to raise risk of esophageal cancer in ADH1B rs1229984 carriers (TC: OR = 1.58, 95% CI: 1.10–2.26, p = 0.013; CC: OR = 4.02, 95% CI: 2.57–6.31, p < 0.001) compared with their counterparts. The gene discussed is ADH1B; the disease is esophageal cancer.