Our finding was consistent with that of a previous study by Yokoyama et al., who reported that individuals with the ADH1B*2 (+) genotype (*1/*2 or *2/*2) and ALDH2*2 (+) genotype (*1/*2 or *2/*2) are likely to suffer from alcohol flushing, preventing alcohol use disorder.24 Here, ALDH2 is linked to alcohol abuse.