The protection conferred by hMTH1 overexpression against mitochondrial insult is consistent with previously reported hMTH1‐mediated prevention of a huntingtin‐related decrease in mitochondrial membrane potential, alterations in mitochondrial morphology and delayed increase in mitochondrial ROS in a cellular model for Huntington's disease (Ventura et al., 2013). Here, HTT is linked to Huntington disease.