Tyrosine phosphorylation of STAT3 in GBM cells suppresses autophagy, whereas knockout (KO) of STAT3 increases ULK1 gene expression, increases TSC2‐AMPKα‐ULK1 signalling, and increases lysosomal Cathepsin D processing, leading to the stimulation of autophagy. The gene discussed is CTSD; the disease is glioblastoma.