Because the expression of DPEP1 and ASCL2 in colon cancer tissues showed a markedly positive correlation, we speculated that there was a mutual regulation between DPEP1 and ASCL2, such regulation including direct or indirect mutual regulation, and more and more studies have demonstrated that this positive feedback loop regulation is common in tumor cells.38, 39. The gene discussed is DPEP1; the disease is malignant colon neoplasm.