SPTA1 and glioblastoma: Interestingly, the mutation rates of PTEN, TTN, EGFR, NF1, TP53, MUC16, and SPTA1 in both groups were higher than 15%, and there were interactions among them to manage multiple tumor-related biological processes in GBM (Figures 6A,B), which indicated that they might be primarily involved in tumor progression.