Moreover, pan-cancer analysis using the GEPIA website for TNFSF12, VDR, and IL1R1 revealed that these three genes had significant expression differences between multiple tumors and normal tissues, and the combined results revealed that TNFSF12, VDR, and IL1R1 also had significant prognostic diversity for multiple tumors (Supplementary Figures S4A–C). This evidence concerns the gene IL1R1 and cancer.