Furthermore, MES1-like and MES2-like tumor cells had high expression levels of immune factors (Figure 4B) (e.g., CSF1, CCL2, CXCL2, CXCL3, CXCL8, CXCL14, IFITM3, IFI6, IFI27, IL1B, IL1RAP, IL6ST, IL13RA2, and IL32), which play important roles in the formation of an immunosuppressive TME (21). This evidence concerns the gene CXCL8 and neoplasm.