NPC1 and neoplasm: Furthermore, we found that AC-like tumor cells were similar to the TCGA-classical subtype and expressed high levels of EGFR. Recently, researchers suggested the removal of the TCGA-neural subtype due to its overlap with the TCGA-proneural subtype (4, 23), and this overlap was also reflected in the overlapping relationship with OPC-like, NPC1-like, and NPC2-like cells in our study.