Furthermore, MES1-like and MES2-like tumor cells had high expression levels of immune factors (Figure 4B) (e.g., CSF1, CCL2, CXCL2, CXCL3, CXCL8, CXCL14, IFITM3, IFI6, IFI27, IL1B, IL1RAP, IL6ST, IL13RA2, and IL32), which play important roles in the formation of an immunosuppressive TME (21). The gene discussed is CXCL3; the disease is neoplasm.