CASP1 and gout: The levels of the NLRP3 inflammasome components IL-1β and active caspase-1 in the peritoneal fluids were significantly increased in MSU intraperitoneally injected mice, and these effects were reduced by oral administration of CS (30 mg/kg/day; total three times before MSU injection) and intraperitoneal injection of colchicine (1 mg/kg; one time before MSU injection), a medication used to treat gout (Figure 7B).