Previous studies illustrated that Th17 cells were found in the vicinity of neuritis plaques in AD brains, along with increased pro-inflammatory cytokines (IL-1β, IL-6, CXCL1, and TNF-α) in peripheral blood, which may contribute to the development of Alzheimer’s disease (40). The gene discussed is CXCL1; the disease is early-onset autosomal dominant Alzheimer disease.