PPARG (Gene Peroxisome Proliferator-Activated Receptor Gamma), a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors, regulates insulin-stimulated genes expression and involves in the pathology of numerous diseases, including diabetes, atherosclerosis, obesity (45). This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.