While in AD, the repressor element 1-silencing transcription/neuron-restrictive silencer factor (REST/NRSF), signal transducer and activator of transcription 3 (STAT3), Nuclear factor erythroid 2 related factor 2 (NRF2) are demonstrated to be significant in the pathogenesis of AD, mainly through regulating gene networks that participate in apoptosis, autophagy, and inflammatory responses (13–15). This evidence concerns the gene REST and Alzheimer disease.