NFE2L2 and Alzheimer disease: While in AD, the repressor element 1-silencing transcription/neuron-restrictive silencer factor (REST/NRSF), signal transducer and activator of transcription 3 (STAT3), Nuclear factor erythroid 2 related factor 2 (NRF2) are demonstrated to be significant in the pathogenesis of AD, mainly through regulating gene networks that participate in apoptosis, autophagy, and inflammatory responses (13–15).