TPSAB1 and melanoma: We next interrogated the TCGA patient data and analyzed the survival for patients whose tumors express high or low mRNA levels of the tryptase gene TPSAB1, and we observed that patients with a higher level of TPSAB1 mRNA exhibited a significantly worse survival rate [log-rank (Mantel–Cox) p < 0.05], suggesting the unfavorable role of MCs in melanoma patient survival (Figure 8A).