In various malignant TMEs, including those fostered by surrounding melanoma, immunosuppressive cytokines, such as TGF-β, and the pro-inflammatory mediators of the IL-1 family, IL-1β and IL-33, have emerged as key facilitators of tumor growth, angiogenesis, and modulators of local immune responses (9–11). The gene discussed is TGFB1; the disease is neoplasm.