C3 and melanoma: A significant increase in C3+ MAMC (tryptase+ C3+) numbers was observed in melanoma (mean: 58.72 cells/mm2, SD: 43.64, n = 82) compared with tryptase+ C3+ healthy skin MCs (mean: 21.25 cells/mm2, SD: 9.85, n = 10) (Figures 3B, D).