Besides γδ T cells, we found approximately a 2-fold increase in the proportion of CD8+ T cells derived from thymus and humanized spleen tissue of HIV-infected BLT huMice as compared to the mock-inoculated mice, suggesting a rapid proliferation of cytotoxic T cells in response to HIV infection (Figures 4A, B, Supplementary Figures S3C, D). The gene discussed is CD8A; the disease is HIV infectious disease.