Through the Cox proportional-hazards models for OS, the univariate analysis indicated that PD-L1, BMI, family history, tumor site, neoadjuvant chemotherapy regimen, duration of neoadjuvant therapy, MPG, positive lymph node (PLN), pathology (ER, Ki-67, CK5/6, E-cad, EGFR, P53), postoperative chemotherapy, postoperative endocrine therapy, targeted therapy were related to the prognosis of breast cancer patients, however, the multivariate analysis found that only PD-L1, duration of neoadjuvant therapy, MPG, PLN, pathology E-cad, targeted therapy were the independent prognostic factors (Table 5). This evidence concerns the gene MKI67 and breast cancer.