According to the Cox proportional-hazards models for DFS, the univariate analysis suggested that PD-L1, tumor site, neoadjuvant chemotherapy regimen, duration of neoadjuvant therapy, pathology (ER, Ki-67, E-cad), postoperative endocrine therapy, and targeted therapy were related to the prognosis of breast cancer patients, however, the multivariate analysis found that only PD-L1, duration of neoadjuvant therapy, pathology E-cad, targeted therapy were the independent prognostic factors (Table 5). The gene discussed is MKI67; the disease is breast carcinoma.