However, in Asano Y’s study, high PD-1 and PD-L1 protein expression was associated with a poorer prognosis in breast cancer patient before undergoing NACT, and low PD-1 and PD-L1 protein expression in TNBC patients was be bound up with a higher pCR rate and significantly longer DFS (44). This evidence concerns the gene PDCD1 and breast carcinoma.