As shown in Figure 1, the expression of STIM1, STIM2, Orai1, and Orai2 were significantly increased in PCOS group (P = 0.037, P = 0.004, P ≤ 0.001, and P = 0.013, respectively), and Orai3 was significantly decreased in GCs of patients with PCOS (P=0.003). This evidence concerns the gene ORAI1 and polycystic ovary syndrome.