Logistic regression showed STIM1 (adjusted OR: 2.253, 95% CI: 1.151–4.414, P = 0.018), STIM2 (adjusted OR: 2.165, 95% CI: 1.091–4.298, P = 0.027), Orai1 (adjusted OR: 8.399, 95% CI: 2.398–29.421, P = 0.001), Orai2 (adjusted OR: 2.129, 95% CI: 1.118–4.055, P = 0.021), and Orai3 (adjusted OR: 0.245, 95% CI: 0.079–0.755, P = 0.014) were factors contributing to the incidence of PCOS. Here, STIM1 is linked to polycystic ovary syndrome.