In summary, for the first time, our findings indicated that SOCE was differently expressed, where STIM1, STIM2, Orai1, and Orai2 significantly increased, whereas Orai3 decreased in PCOS GCs, which might be dominantly involved in dysfunction of ovarian GCs and hormone changes in PCOS. The gene discussed is STIM1; the disease is polycystic ovary syndrome.