Exposure: Pre-pregnancy overweight/obesity (unclear how measured), GDM.Outcome: Measured cardiometabolic biomarkers from blood, measured BP, resting HRAscertainment of outcome: Fasting glucose, insulin, SHBG, HDL, LDL, TG, lipoprotein, ApoA1, ApoB, FFA, testosterone, uric acid, CRP, ALT, AST, GGT, SBP, DBP, HR. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.