Exposure: Pre-pregnancy overweight/obesity (unclear how measured), GDM.Outcome: Measured cardiometabolic biomarkers from blood, measured BP, resting HRAscertainment of outcome: Fasting glucose, insulin, SHBG, HDL, LDL, TG, lipoprotein, ApoA1, ApoB, FFA, testosterone, uric acid, CRP, ALT, AST, GGT, SBP, DBP, HR. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.