Exposure: Pre-pregnancy overweight/obesity (unclear how measured), GDM.Outcome: Measured cardiometabolic biomarkers from blood, measured BP, resting HRAscertainment of outcome: Fasting glucose, insulin, SHBG, HDL, LDL, TG, lipoprotein, ApoA1, ApoB, FFA, testosterone, uric acid, CRP, ALT, AST, GGT, SBP, DBP, HR. This evidence concerns the gene APOA1 and obesity due to melanocortin 4 receptor deficiency.