Moreover, EV-CPC-P cargo is enriched with VEGF and its receptors (VEGFR2 and VEGFR3) that are involved in the stimulation of angiogenesis, essential to prevent heart failure through the control of cardiomyocyte hypertrophy and contractility (Gogiraju et al., 2019; Di Meglio et al., 2012) and to improve cardiac function (Dougherty et al., 2020). Here, KDR is linked to heart failure.