HGF and heart disorder: EV-CPC-P, instead, transport considerably higher amount of growth factors mainly involved in the induction of fibroblast transdifferentiation towards myofibroblasts (TGF-β and HGF), strengthening the hypothesis that cardiac disease affects CPC compartment too (Nurzynska et al., 2013), and that the release of pro-fibrotic factors by EV-CPC-P could be involved in sustaining the pathological remodeling affecting the ischemic heart.