Additionally, we observed in vitro the fibronectin disarrangement that has been previously described in post-ischemic cardiac fibrosis (Berezin and Berezin, 2020) and, interestingly, the administration of EV-CPC-N to CF-P in vitro conferred to fibronectin deposition an organized fibrillary pattern (Figure 8) inducing to speculate that EV-CPC-N positively affect the extracellular compartment during the response to injury. Here, FN1 is linked to cystic fibrosis.